Kurogochi et al: Saline‐based modified del Nido cardioplegia versus multidose St. Thomas cardioplegia in canine mitral valve repair: A randomized controlled trial
Veterinary Surgery 7, 2025

🔍 Key Findings

• No significant difference in cardiac troponin I levels 12h post-op between mDN and St. Thomas cardioplegia groups (p = 0.478)
• Sinus rhythm returned faster in the mDN group after aortic cross-clamp removal (median 60s vs 362s, p = 0.027)
• Lower serum potassium at cross-clamp removal in the mDN group (median 4.5 mEq/L vs 5.4, p = 0.005)
• Fewer doses needed in the mDN group (median 2.5 vs 4.0, p = 0.040)
• Higher total crystalloid volume used in mDN group (23.6 vs 12.6 mL/kg, p < 0.001)
• No difference in survival (700-day survival 90% in both groups, p = 0.958)
• No difference in hospitalization duration (median 6 days for both, p = 0.789)
• Echocardiographic remodeling similar between groups at 24h post-op