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Kurogochi et al: Saline‐based modified del Nido cardioplegia versus multidose St. Thomas cardioplegia in canine mitral valve repair: A randomized controlled trial
Veterinary Surgery 7, 2025

🔍 Key Findings

  • No significant difference in cardiac troponin I levels 12h post-op between mDN and St. Thomas cardioplegia groups (p = 0.478)
  • Sinus rhythm returned faster in the mDN group after aortic cross-clamp removal (median 60s vs 362s, p = 0.027)
  • Lower serum potassium at cross-clamp removal in the mDN group (median 4.5 mEq/L vs 5.4, p = 0.005)
  • Fewer doses needed in the mDN group (median 2.5 vs 4.0, p = 0.040)
  • Higher total crystalloid volume used in mDN group (23.6 vs 12.6 mL/kg, p < 0.001)
  • No difference in survival (700-day survival 90% in both groups, p = 0.958)
  • No difference in hospitalization duration (median 6 days for both, p = 0.789)
  • Echocardiographic remodeling similar between groups at 24h post-op

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← Articles

Kurogochi et al: Saline‐based modified del Nido cardioplegia versus multidose St. Thomas cardioplegia in canine mitral valve repair: A randomized controlled trial
Veterinary Surgery 7, 2025

🔍 Key Findings

  • No significant difference in cardiac troponin I levels 12h post-op between mDN and St. Thomas cardioplegia groups (p = 0.478)
  • Sinus rhythm returned faster in the mDN group after aortic cross-clamp removal (median 60s vs 362s, p = 0.027)
  • Lower serum potassium at cross-clamp removal in the mDN group (median 4.5 mEq/L vs 5.4, p = 0.005)
  • Fewer doses needed in the mDN group (median 2.5 vs 4.0, p = 0.040)
  • Higher total crystalloid volume used in mDN group (23.6 vs 12.6 mL/kg, p < 0.001)
  • No difference in survival (700-day survival 90% in both groups, p = 0.958)
  • No difference in hospitalization duration (median 6 days for both, p = 0.789)
  • Echocardiographic remodeling similar between groups at 24h post-op

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Multiple Choice Questions on this study

In Kurogochi 2025 et al., on cardioplegia in mitral repair, what was concluded about long-term outcomes between groups?

A. mDN had higher survival at 700 days
B. Control group had better hospitalization outcomes
C. No differences in survival or hospitalization duration
D. mDN had lower discharge rates
E. mDN was associated with more complications

Answer: No differences in survival or hospitalization duration

Explanation: Survival at 700 days was 90% in both groups; hospital stay was median 6 days.
In Kurogochi 2025 et al., on cardioplegia in mitral repair, what difference was found in serum potassium at cross-clamp removal?

A. Potassium was higher in the mDN group
B. Potassium was equal between groups
C. Potassium was higher in control group
D. Potassium was below normal in both groups
E. Potassium was unmeasurable in mDN group

Answer: Potassium was higher in control group

Explanation: Potassium at cross-clamp removal was higher in control group (5.4 vs 4.5 mEq/L, p = 0.005).
In Kurogochi 2025 et al., on cardioplegia in mitral repair, what was the effect of mDN solution on sinus rhythm recovery?

A. It delayed sinus rhythm recovery compared to the control group
B. It had no significant impact on sinus rhythm recovery
C. It resulted in significantly faster sinus rhythm recovery
D. It led to a higher defibrillation rate
E. It caused arrhythmias post-cross-clamp

Answer: It resulted in significantly faster sinus rhythm recovery

Explanation: Faster sinus rhythm recovery in the mDN group (60s vs 362s, p = 0.027) suggests electrical stabilization benefits.
In Kurogochi 2025 et al., on cardioplegia in mitral repair, what was the main finding regarding serum cardiac troponin I levels 12 hours post-op?

A. They were significantly lower in the mDN group
B. They were significantly higher in the mDN group
C. They were comparable between both groups
D. Only control group showed elevation
E. Only mDN group showed elevation

Answer: They were comparable between both groups

Explanation: There was no significant difference in cTnI levels at 12h post-op (p = 0.478).
In Kurogochi 2025 et al., on cardioplegia in mitral repair, how did the number of cardioplegia doses differ between groups?

A. mDN group required more doses
B. Control group required fewer doses
C. Both groups required the same doses
D. mDN group received none
E. Dosing was not reported

Answer: Control group required fewer doses

Explanation: mDN group needed fewer total doses (median 2.5 vs 4, p = 0.040).

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