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Murphy et al: The Prevalence and Risk Factors of Contralateral Cranial Cruciate Ligament Rupture in Medium-to-Large (≥15kg) Breed Dogs 8 Years of Age or Older
Veterinary and Comparative Orthopedics and Traumatology 1, 2024

🔍 Key Findings Summary

  • Prevalence of contralateral CCLR in dogs ≥8 years and ≥15kg was 19.1%, notably lower than previous studies (33–50%).
  • Median time to contralateral CCLR was 12.9 months.
  • Older age reduced risk — 2% decrease per month of age (p=0.003).
  • Golden Retrievers and Labradors had significantly lower risk (p=0.028 and p=0.007, respectively).
  • No effect found from TPA, meniscal injury, or comorbidities (e.g., hip dysplasia, hypothyroidism).

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← Articles

Murphy et al: The Prevalence and Risk Factors of Contralateral Cranial Cruciate Ligament Rupture in Medium-to-Large (≥15kg) Breed Dogs 8 Years of Age or Older
Veterinary and Comparative Orthopedics and Traumatology 1, 2024

🔍 Key Findings Summary

  • Prevalence of contralateral CCLR in dogs ≥8 years and ≥15kg was 19.1%, notably lower than previous studies (33–50%).
  • Median time to contralateral CCLR was 12.9 months.
  • Older age reduced risk — 2% decrease per month of age (p=0.003).
  • Golden Retrievers and Labradors had significantly lower risk (p=0.028 and p=0.007, respectively).
  • No effect found from TPA, meniscal injury, or comorbidities (e.g., hip dysplasia, hypothyroidism).

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Multiple Choice Questions on this study

In Murphy 2024 et al., what was the median time from first-side CCLR to contralateral rupture?

A. 5.5 months
B. 7.3 months
C. 9.8 months
D. 12.9 months
E. 16.5 months

Answer: 12.9 months

Explanation: Median time to contralateral CCLR was 12.9 months (25th–75th percentile: 6.5–24.3 months).
In Murphy 2024 et al., which factor was **not** significantly associated with contralateral CCLR risk?

A. Breed
B. Age
C. Tibial plateau angle (TPA)
D. Golden Retriever
E. Labrador Retriever

Answer: Tibial plateau angle (TPA)

Explanation: Multivariate analysis found TPA, comorbidities, and meniscal status were **not** significant risk factors.
In Murphy 2024 et al., what was the overall prevalence of contralateral CCLR in dogs ≥8 years and ≥15kg?

A. 12.5%
B. 19.1%
C. 27.6%
D. 33.1%
E. 48.0%

Answer: 19.1%

Explanation: Contralateral CCLR occurred in 159/831 dogs, or 19.1%, lower than prior reports of 33–48% prevalence.
In Murphy 2024 et al., which breeds had significantly lower odds of contralateral CCLR?

A. German Shepherd and Rottweiler
B. Labrador Retriever and Golden Retriever
C. Golden Retriever and Boxer
D. Labrador Retriever and Australian Shepherd
E. Golden Retriever and Mixed Breed

Answer: Labrador Retriever and Golden Retriever

Explanation: Both breeds had significantly lower odds: Labradors (OR 0.58, p=0.007) and Goldens (OR 0.47, p=0.028).
In Murphy 2024 et al., which factor was associated with decreased odds of contralateral CCLR per month?

A. Tibial plateau angle
B. TPLO timing
C. Age
D. Sex
E. Body weight

Answer: Age

Explanation: Each 1-month increase in age decreased the odds of contralateral rupture by 2% (OR 0.98, p=0.003).

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