🔍 Key Findings
- Local recurrence occurred in 17.8% of dogs, and was associated with significantly decreased survival (551 vs 1722 days, p = .0038).
- Lymph node metastasis occurred in 26.7% of dogs and was significantly associated with shorter disease-free interval (194 vs not reached, p = .0012) and lower survival (551 vs 1722 days, p = .043).
- Mitotic index >7 was significantly associated with higher recurrence (80% vs 22.5%, p = .02), shorter DFI (139 vs not reached days, p < .001), and shorter survival (247 vs 1722 days, p = .05).
- Infiltrative growth pattern was associated with shorter DFI (268 vs 1864 days, p = .011), but not with survival or recurrence.
- Incomplete margins (≤1 mm) were not significantly associated with recurrence (p = .085), but did correlate with shorter DFI (p = .043).
- Chemotherapy or radiation therapy was associated with shorter DFI and survival, likely due to selection bias for more aggressive disease.
- Tumor size >3 cm was associated with decreased survival (p = .031), but not with recurrence or DFI.
- Multinucleation and necrosis were not associated with prognosis outcomes.
