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Cherzan et al: Factors affecting prognosis in canine subcutaneous mast cell tumors: 45 cases
Veterinary Surgery 4, 2023

🔍 Key Findings

  • Local recurrence occurred in 17.8% of dogs, and was associated with significantly decreased survival (551 vs 1722 days, p = .0038).
  • Lymph node metastasis occurred in 26.7% of dogs and was significantly associated with shorter disease-free interval (194 vs not reached, p = .0012) and lower survival (551 vs 1722 days, p = .043).
  • Mitotic index >7 was significantly associated with higher recurrence (80% vs 22.5%, p = .02), shorter DFI (139 vs not reached days, p < .001), and shorter survival (247 vs 1722 days, p = .05).
  • Infiltrative growth pattern was associated with shorter DFI (268 vs 1864 days, p = .011), but not with survival or recurrence.
  • Incomplete margins (≤1 mm) were not significantly associated with recurrence (p = .085), but did correlate with shorter DFI (p = .043).
  • Chemotherapy or radiation therapy was associated with shorter DFI and survival, likely due to selection bias for more aggressive disease.
  • Tumor size >3 cm was associated with decreased survival (p = .031), but not with recurrence or DFI.
  • Multinucleation and necrosis were not associated with prognosis outcomes.

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← Articles

Cherzan et al: Factors affecting prognosis in canine subcutaneous mast cell tumors: 45 cases
Veterinary Surgery 4, 2023

🔍 Key Findings

  • Local recurrence occurred in 17.8% of dogs, and was associated with significantly decreased survival (551 vs 1722 days, p = .0038).
  • Lymph node metastasis occurred in 26.7% of dogs and was significantly associated with shorter disease-free interval (194 vs not reached, p = .0012) and lower survival (551 vs 1722 days, p = .043).
  • Mitotic index >7 was significantly associated with higher recurrence (80% vs 22.5%, p = .02), shorter DFI (139 vs not reached days, p < .001), and shorter survival (247 vs 1722 days, p = .05).
  • Infiltrative growth pattern was associated with shorter DFI (268 vs 1864 days, p = .011), but not with survival or recurrence.
  • Incomplete margins (≤1 mm) were not significantly associated with recurrence (p = .085), but did correlate with shorter DFI (p = .043).
  • Chemotherapy or radiation therapy was associated with shorter DFI and survival, likely due to selection bias for more aggressive disease.
  • Tumor size >3 cm was associated with decreased survival (p = .031), but not with recurrence or DFI.
  • Multinucleation and necrosis were not associated with prognosis outcomes.

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Multiple Choice Questions on this study

In Cherzan 2023 et al., on subcutaneous mast cell tumors, which characteristic was **not** significantly associated with recurrence, DFI, or survival in dogs with subcutaneous mast cell tumors?

A. Infiltrative pattern
B. Mitotic index >7
C. Lymph node metastasis
D. Multinucleation
E. Local recurrence

Answer: Multinucleation

Explanation: Multinucleation was evaluated but not found to impact prognosis in this study.
In Cherzan 2023 et al., on subcutaneous mast cell tumors, what proportion of dogs with lymph node metastases developed tumor recurrence?

A. 17.8%
B. 26.7%
C. 44%
D. 67%
E. 80%

Answer: 67%

Explanation: 67% (8 of 12) of dogs with LN metastases experienced tumor recurrence.
In Cherzan 2023 et al., on subcutaneous mast cell tumors, what was the median disease-free interval (DFI) for dogs with lymph node metastasis from subcutaneous mast cell tumors?

A. Not reached
B. 551 days
C. 268 days
D. 194 days
E. 139 days

Answer: 194 days

Explanation: Lymph node metastasis significantly reduced DFI to a median of 194 days.
In Cherzan 2023 et al., on subcutaneous mast cell tumors, what impact did incomplete surgical margins (<1 mm) have on recurrence rates of subcutaneous mast cell tumors?

A. They significantly increased recurrence
B. They significantly decreased recurrence
C. They had no significant impact on recurrence
D. They improved DFI
E. They improved survival

Answer: They had no significant impact on recurrence

Explanation: Incomplete margins were not significantly associated with recurrence (*p* = .085).
In Cherzan 2023 et al., on subcutaneous mast cell tumors, which histologic feature was most strongly associated with shorter disease-free interval and survival time?

A. Muscle invasion
B. Infiltrative growth pattern
C. Multinucleation
D. Mitotic index >7
E. Necrosis

Answer: Mitotic index >7

Explanation: Mitotic index >7 was associated with higher recurrence, shorter DFI, and shorter survival.

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