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Bush et al: Outcomes and clinical features associated with surgically excised canine salivary gland carcinoma: A multi-institutional, retrospective, Veterinary Society of Surgical Oncology study
Veterinary Surgery 3, 2023

🔍 Key Findings

Source: Bush et al., 2023, Veterinary Surgery

  • Median survival time (MST) after surgery was 1886 days, which is significantly longer than previously reported.
  • Lymph node metastasis at surgery was a negative prognostic factor, reducing MST to 248 days (vs. 2340 days without nodal involvement).
  • Local recurrence occurred in 42% of dogs, with a median disease-free interval (DFI) of 191 days.
  • Metastatic disease occurred in 32% of dogs, most commonly to the lungs, with a median DFI of 299 days.
  • Histologic features (e.g., margin status, capsular, lymphatic, or vascular invasion) were not significantly correlated with recurrence or metastasis.
  • Facial nerve injury occurred in 9.7% perioperatively, especially after parotidectomy; intraoperative facial nerve transection led to long-term deficits.
  • Adjuvant therapies (chemotherapy, radiation, NSAIDs) did not significantly affect survival time.
  • Incisional biopsy was only 38% concordant with final excisional histology, suggesting limited reliability for definitive diagnosis.

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← Articles

Bush et al: Outcomes and clinical features associated with surgically excised canine salivary gland carcinoma: A multi-institutional, retrospective, Veterinary Society of Surgical Oncology study
Veterinary Surgery 3, 2023

🔍 Key Findings

Source: Bush et al., 2023, Veterinary Surgery

  • Median survival time (MST) after surgery was 1886 days, which is significantly longer than previously reported.
  • Lymph node metastasis at surgery was a negative prognostic factor, reducing MST to 248 days (vs. 2340 days without nodal involvement).
  • Local recurrence occurred in 42% of dogs, with a median disease-free interval (DFI) of 191 days.
  • Metastatic disease occurred in 32% of dogs, most commonly to the lungs, with a median DFI of 299 days.
  • Histologic features (e.g., margin status, capsular, lymphatic, or vascular invasion) were not significantly correlated with recurrence or metastasis.
  • Facial nerve injury occurred in 9.7% perioperatively, especially after parotidectomy; intraoperative facial nerve transection led to long-term deficits.
  • Adjuvant therapies (chemotherapy, radiation, NSAIDs) did not significantly affect survival time.
  • Incisional biopsy was only 38% concordant with final excisional histology, suggesting limited reliability for definitive diagnosis.

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Multiple Choice Questions on this study

In Bush 2023 et al., on canine salivary gland carcinoma, which factor was associated with significantly shorter survival and disease-free interval (DFI)?

A. Facial nerve injury
B. Chemotherapy use
C. Parotid gland involvement
D. Lymph node metastasis
E. Positive surgical margins

Answer: Lymph node metastasis

Explanation: Dogs with nodal metastasis had an MST of 248 days versus 2340 days without, and shorter DFI.
In Bush 2023 et al., on canine salivary gland carcinoma, what was the concordance rate between incisional biopsy and final excisional histopathology?

A. 92%
B. 38%
C. 61%
D. 75%
E. 47%

Answer: 38%

Explanation: Only 38.4% of incisional biopsies were completely concordant with final excisional histology.
In Bush 2023 et al., on canine salivary gland carcinoma, which complication was most commonly associated with parotid gland excision?

A. Hypocalcemia
B. Swelling
C. Salivary mucocele
D. Facial nerve injury
E. Hematoma

Answer: Facial nerve injury

Explanation: Facial nerve injury was exclusive to parotid sialoadenectomy cases in the study.
In Bush 2023 et al., on canine salivary gland carcinoma, what was the rate of local recurrence after surgical excision of salivary carcinoma in dogs?

A. 10%
B. 19%
C. 26%
D. 42%
E. 58%

Answer: 42%

Explanation: Local recurrence (confirmed or suspected) occurred in 42% of cases, with a median DFI of 191 days.
In Bush 2023 et al., on canine salivary gland carcinoma, what was the median survival time (MST) for dogs undergoing surgery?

A. 550 days
B. 248 days
C. 918 days
D. 1886 days
E. 3016 days

Answer: 1886 days

Explanation: Surgically treated dogs had an MST of 1886 days, significantly longer than previously reported.

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