🔍 Key Findings

Objective: Determine if topical 45 mg/mL amikacin in CMC gel leads to systemic absorption in dogs with wounds.

Dogs enrolled: 11 client-owned dogs, with 31 applications of the gel.

Serum findings:

• Only 5 of 153 samples were above the 2.5 µg/mL quantification limit
• All values remained <5 µg/mL, the presumed toxicity threshold
• No correlation was found between dose-related parameters (mg, mg/kg, mg/cm²) and serum amikacin levels

Peak concentrations were observed at ~2 hours post-application, declining rapidly thereafter

No nephrotoxicity observed, and most values were below detection

Conclusion: Topical amikacin gel appears safe at doses up to 24.9 mg/kg, with minimal systemic absorption

🔍 Key Findings

• Double forwarder (DF) knots had significantly higher knot holding capacity (KHC) than square (SQ) and surgeon’s (SU) knots when tied with <6 throws.
• In 3 USP polyglactin 910, DF knots with 4–5 throws were not significantly stronger than SU knots with 6–8 throws (p > .43).
• DF knots never unraveled, while SQ and SU knots with 4–5 throws showed substantial unraveling.
• KHC did not increase in DF knots when throws increased from 3 to 5.
• Knot volume and weight were significantly higher in DF knots than SQ/SU knots at the same throw count (p < .003).
• DF knots allow sliding placement, potentially useful in minimally invasive or deep cavity procedures.

🔍 Key Findings

• Hybrid implants were used in older, heavier dogs with lower canal flare index (CFI) compared to cementless types.
• CFI <1.8 was associated with higher risk of femoral fracture or stem subsidence with cementless implants.
• Total complication rate was 14%, with catastrophic complications in only 1.5%—lower than reported in other studies.
• No significant difference in complication rates across implant types (BFX, BFX-C, hybrid).
• Femur fractures were rare (2.9%), lower than in prior studies, and successfully managed with cerclage/plate fixation.
• Coxofemoral luxation was the most common complication (8 cases); all occurred within 62 days post-op, mostly resolved with revision.
• Collared BFX stems did not significantly reduce complications, though they may limit stem subsidence.
• An implant selection algorithm was proposed, using age ≥7 years, weight ≥45 kg, and CFI <1.8 to guide cemented vs. cementless stem use.

🔍 Key Findings

• 14 joints from 7 cat cadavers underwent AA-HTS successfully.
• Median surgical time: 46.5 min (29–144), including 7 min for arthroscopy and 40 min for toggle placement.
• Intraoperative complications in 5/14 joints: 4 related to femoral tunnel creation, 1 toggle lodging.
• Toggle passage through femoral tunnel was the most challenging step, mildly difficult in 6 joints.
• Cartilage injury occurred in 10 joints, but all were minor (<10% of cartilage area).
• 13 deviations from planned technique were identified (8 major, 5 minor), all involving femoral tunnel placement.
• No neurovascular, intrapelvic, or major periarticular injuries occurred.
• Authors conclude: AA-HTS is feasible in cats, but associated with high rates of minor iatrogenic cartilage damage, intra-op complications, and technique deviations.

🔍 Key Findings

• FGPP (fluoroscopic-guided percutaneous pinning) resulted in successful healing in 10/13 fractures, with good limb function.
• Complications occurred in 5 of 11 cases, including intra-articular implants, malunion, implant failure/nonunion, and implant migration.
• Cases with delayed surgery (>15 days) or radiographic remodeling were more likely to experience major complications.
• Most fractures (10/13) were classified as Salter-Harris type I with mild displacement.
• Median surgical time was 60 minutes, and no conversions to open surgery were needed.
• Postoperative femoral neck resorption was minimal, suggesting possible benefits of the minimally invasive approach for preserving vascular supply.
• One intra-articular pin led to progressive joint disease and required femoral head ostectomy.
• FGPP appears best suited for acute, minimally displaced fractures in young dogs (<8 months) with planned elective explant to avoid growth disturbance.

🔍 Key Findings Summary

• No significant difference in mechanical properties between contoured vs non-contoured SOP-LC rods
• Clamp configuration significantly influenced mechanical performance:
  • Single-side clamps → ↑ yield load, ↑ displacement, ↑ bending strength (p < 0.05)
  • Alternating-side clamps → ↑ initial torsional stiffness (p = 0.029)
• Clamp slippage was evident only in torsional tests; screw loosening may be torque-dependent
• Mild screw bending and construct offset suggest subtle instability
• Recommends clamp configuration choice based on loading scenario
• Suggests 3.0 Nm torque may be more effective than 2.5 Nm to prevent clamp slippage

🔍 Key Findings

• Barbed sutures showed comparable leakage pressure to traditional sutures and stapling devices (p = .36).
• No bronchial leaks occurred at physiological pressure (<20 cmH₂O) in any group.
• Leakage at supraphysiologic pressure (20–80 cmH₂O) occurred in 90% of stapler, 80% of traditional, and 60% of barbed suture closures.
• Barbed sutures reduced ligation time significantly compared to traditional sutures (10.7 vs. 14.1 minutes, p < .01).
• Staplers remained fastest, with mean ligation time of 2.4 minutes.
• No knot failure or suture breakage was observed in barbed or traditional suture groups.
• Leakage in barbed sutures occurred mostly at the loop effector zone, but remained within acceptable limits.
• Barbed sutures may offer an effective alternative when staplers are unavailable, impractical, or cost-prohibitive.

🔍 Key Findings

• 12-hole LCPs (80% plate–bone ratio) showed significantly higher construct stiffness than 6-, 8-, or 10-hole plates in both compression and tension bending.
• Strain on the plate was significantly lower in 12-hole vs 6-hole plates at all regions of interest (ROIs), especially around the fracture gap.
• No incremental increases in stiffness or decreases in strain were observed between 6-, 8-, and 10-hole plates—only when comparing to 12-hole plates.
• Bone model strain adjacent to the plate end was significantly lower for 10- and 12-hole plates vs 6-hole plates under both loading conditions.
• The threshold effect suggests biomechanical benefits only emerge beyond a plate–bone ratio of ~80%.
• Working length increased from 9.4 mm (6-hole) to 13 mm (others), potentially influencing strain/stiffness differences.
• Four-point bending was used, as it replicates the most biomechanically relevant force on plated long bones.
• Clinical implication: Longer plates may reduce plate strain and peri-implant bone strain, potentially lowering risk of fatigue failure or stress risers.

🔍 Key Findings

• Buccal transposition flap provided successful closure of large maxillary lip defects in all 5 dogs
• All flaps survived, with 3 dogs experiencing minor complications (e.g., fistulas, dehiscence) that resolved
• Flap vascularization originated from the angularis oris and superior labial arteries, as confirmed via CT angiography
• Excellent cosmetic and functional outcomes were achieved in all cases
• Ex vivo cadaver study validated flap perfusion, showing consistent contrast filling of key arteries
• Oronasal fistulas occurred in 2 dogs at the palatal incision site, likely due to contact with the mandibular canine tooth
• Mandibular canine coronectomy was performed in 2/5 dogs to prevent flap trauma
• Flap design and commissure positioning were customizable, aiding tension relief and improving outcomes