🔍 Key Findings
- BLIS (bupivacaine liposome injectable solution) provided equivalent analgesia to fentanyl CRI based on CMPS-SF scores at all time points except 6h, where BLIS was superior
- Fewer adverse effects (nausea, vomiting, sedation) were noted in the BLIS group
- BLIS dogs ate sooner postoperatively (median 6h vs 9h in control)
- Sedation occurred in 2/20 dogs in BLIS group vs 10/20 in fentanyl group
- Vomiting occurred in 0/20 BLIS dogs vs 4/20 in fentanyl group
- Rescue analgesia rates were similar (5 BLIS vs 4 fentanyl group), confirming noninferiority
- Owner-reported VAS scores were lower for BLIS on day 1 a.m. and p.m. despite variability
- Results suggest BLIS could reduce opioid reliance post-amputation
