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Haine et al: Incomplete histological margins following planned narrow excision of canine appendicular soft tissue sarcomas and mast cell tumors, using the residual tumor classification scheme
Veterinary Surgery 7, 2022

🔍 Key Findings

  • Fewer R1 margins (tumor on ink) were achieved in mast cell tumors (MCTs) when using 6–10 mm lateral margins versus 0–5 mm (7% vs. 55%; _P_ = .049).
  • For soft tissue sarcomas (STSs), no benefit was seen in margin completeness between 0–5 mm vs. 6–10 mm lateral margins (41% vs. 43% R1).
  • Overall R1 rates were 26% for MCTs and 42% for STSs following PNE.
  • R scheme (“tumor on ink” = R1) had better interobserver agreement (83%) compared to ≤1 mm margin criteria (68% agreement).
  • Complication rate was moderate (26%), but no surgeries required revision.
  • Local recurrence/metastasis occurred in 14% of dogs, with 60% of those having R1 margins.
  • Adjunctive therapy was considered clinically indicated in 46% of 0–5 mm margin cases vs. 24% of 6–10 mm cases.
  • Histologic grade and tumor size were not predictive of margin completeness.

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← Articles

Haine et al: Incomplete histological margins following planned narrow excision of canine appendicular soft tissue sarcomas and mast cell tumors, using the residual tumor classification scheme
Veterinary Surgery 7, 2022

🔍 Key Findings

  • Fewer R1 margins (tumor on ink) were achieved in mast cell tumors (MCTs) when using 6–10 mm lateral margins versus 0–5 mm (7% vs. 55%; _P_ = .049).
  • For soft tissue sarcomas (STSs), no benefit was seen in margin completeness between 0–5 mm vs. 6–10 mm lateral margins (41% vs. 43% R1).
  • Overall R1 rates were 26% for MCTs and 42% for STSs following PNE.
  • R scheme (“tumor on ink” = R1) had better interobserver agreement (83%) compared to ≤1 mm margin criteria (68% agreement).
  • Complication rate was moderate (26%), but no surgeries required revision.
  • Local recurrence/metastasis occurred in 14% of dogs, with 60% of those having R1 margins.
  • Adjunctive therapy was considered clinically indicated in 46% of 0–5 mm margin cases vs. 24% of 6–10 mm cases.
  • Histologic grade and tumor size were not predictive of margin completeness.

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Multiple Choice Questions on this study

In Haine 2022 et al., on outcomes in canine limb tumors, which scheme demonstrated greater interobserver agreement?

A. The ≤1 mm scheme
B. The Patnaik scheme
C. The Kiupel grading system
D. The R classification scheme
E. The WHO margin system

Answer: The R classification scheme

Explanation: The R scheme showed 83% agreement versus 68% with the ≤1 mm scheme.
In Haine 2022 et al., on outcomes in canine limb tumors, what proportion of dogs developed local recurrence or metastasis postoperatively?

A. 5%
B. 14%
C. 25%
D. 34%
E. 50%

Answer: 14%

Explanation: 14% of dogs had recurrence/metastasis, and 60% of those had R1 margins.
In Haine 2022 et al., on outcomes in canine limb tumors, what was the overall R1 rate following planned narrow excision for soft tissue sarcomas?

A. 12%
B. 26%
C. 34%
D. 42%
E. 55%

Answer: 42%

Explanation: STSs had a 42% R1 rate vs 26% for MCTs in the study.
In Haine 2022 et al., on outcomes in canine limb tumors, which lateral surgical margin width significantly reduced R1 margin rates?

A. 1–2 mm
B. 3–5 mm
C. 6–10 mm
D. >10 mm
E. There was no difference

Answer: 6–10 mm

Explanation: Only 7% had R1 margins with 6–10 mm margins versus 55% for 0–5 mm.
In Haine 2022 et al., on outcomes in canine limb tumors, which best describes the surgical complication profile for PNE procedures?

A. No complications reported
B. Over 50% required surgical revision
C. High rate of wound dehiscence
D. Moderate complication rate, no revisions needed
E. All cases had major complications

Answer: Moderate complication rate, no revisions needed

Explanation: 26% had minor complications, but none required additional surgery.

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